Home Research CRISPR based genetic research gets easier with this new software

CRISPR based genetic research gets easier with this new software


Genetic research using CRISPR has picked up lately ever since gene editing system CRISPR-CAS9 was derived from this technology and to facilitate better and efficient use of this technology researchers have recently generated a web-based software, Green Listed.

The software created by scientists at Karolinska Institutet and the University of Gothenburg facilitates the use of the CRISPR methodology and is freely available through greenlisted.cmm.ki.se. Scientists have also made available information about CRISPR and related information about the software in the form of textual content as well as videos.

CRISPR is a research method that can be used to rapidly study how different portions of the DNA directly affect cells. Using this method, researchers can gain insights to the cause of diseases and give suggestions for how they can be treated. The method has ample of applications including its use in study of both immune cells and cancer cells. Through study of these cells, scientists around the world intend to develop new treatments for patients with diseases related to the immune system, such as arthritis, as well as cancer.

The CRISPR method is based on a system that is found naturally in many bacteria and the method has received a lot of attention in the last few years. A very powerful way to use CRISPR is to in parallel study different parts of the DNA simultaneously, a so called CRISPR screen. “Green Listed” is specifically used to facilitate this type of large-scale studies.

Scientists have long equated DNA as a cookbook with each type of cells carrying their own cookbooks inside them. There are different group of cells and each of these cells use recipes of the cookbook in different ways. Quite a few diseases that we suffer from today can be explained by the existence of changes in the DNA of the affected patient.

So if we take the cookbook metaphor into considering, one or more recipes in the cookbook have been changed. So consider the case of one tablespoon of sugar being changed to a tablespoon of salt. This effectively means that quite a few disease occur due to this change in recipe or DNA. With the CRISPR method, we can quickly make change to the DNA in individual isolated cells and thereby learn about the diseases as well as genetic ways of treating them.